|
T8982 |
RH01687
|
|
Others
|
|
RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress. |
|
T2055 |
WS3
|
|
EGFR
,
IκB/IKK
|
|
WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
|
T15159 |
Dorzagliatin
|
HMS5552 |
Glucokinase
|
|
Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes. |
|
T1603 |
Glipizide
|
CP 28720,K 4024 |
Potassium Channel
,
PPAR
,
ABC
|
|
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity. |
|
TP1382L |
HAEGTFTSDVS acetate
|
HAEGTFTSDVS acetate(864915-61-7 free base) |
Glucagon Receptor
|
|
HAEGTFTSDVS acetate is the first N-terminal 1-11 residues of GLP-1 which stimulates insulin secretion from pancreatic β-cells. |
|
T1755 |
LY2090314
|
|
GSK-3
|
|
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a... |
|
TP1125 |
Insulin(cattle)
|
Insulin from bovine pancreas |
IGF-1R
|
|
Insulin bovine (Insulin from bovine pancreas) is a biologically derived two-chain polypeptide hormone, synthesized in vivo by pancreatic β cells. It is frequently utilized as a growth supplement in cell culture applicati... |
|
T6961 |
PX-478
|
PX-478 2HCl |
HIF/HIF Prolyl-Hydroxylase
,
HIF
,
Autophagy
|
|
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di... |
|
T3984 |
GLP-1(7-36), amide
|
MKC 253,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide |
Glucagon Receptor
|
|
GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-... |
|
T4400 |
DIM-C-pPhOH
|
CDIM8 |
Apoptosis
,
Others
|
|
DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi... |
|
T3162 |
IDE1
|
|
Others
|
|
IDE1 can induce definitive endoderm from embryonic stem cells. It has been shown to induce the differentiation of Sox17+/FoxA2+-expressing pancreatic progenitors from human and mouse embryonic stems cells (EC50: 125.5 nM... |
|
T27736 |
KM10103
|
KM-10103,KM 10103 |
|
|
KM10103 exhibits β-cell-protective activities against ER stress, which plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes. |
|
TP1202 |
Calcitonin Gene Related Peptide (CGRP) II, rat
|
CGRP II, rat |
|
|
Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes. |
|
T26895 |
BRD0476
|
BRD-0476,ML 187,ML187,ML-187,BRD 0476 |
|
|
BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell ... |
|
T35627 |
Amylin (human) (trifluoroacetate salt)
|
|
|
|
Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values... |
|
T29154 |
WB403
|
WB-403,WB 403 |
|
|
WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores th... |
|
T28157 |
Nephrin
|
|
|
|
Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. N... |
|
T22860 |
Imeglimin
|
|
Others
|
|
Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents. It has been shown to act on the liver, muscle, and pancreatic β-cells to uniquely target the key defects of type 2 diabetes... |
|
TP2017 |
GIP (1-39)
|
|
|
|
Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP. |
|
TP1630 |
A-71915 TFA (132956-87-7 free base)
|
A-71915 TFA |
|
|
A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells. |
|
T76037 |
A-71915 TFA
|
|
|
|
A-71915 (TFA) is a selective atrial natriuretic peptide-receptor (ANP receptor) inhibitor that promotes apoptosis and reduces insulin secretion in RINm5F pancreatic β-cells [1]. |
|
T61040 |
Vin-F03
|
|
|
|
Vin-F03 can be used in the research of type 2 diabetes mellitus that is an effective protective agent of pancreatic β-cells (EC50 = 0.27 μM). Vin-F03 potently promotes the survival of β-cell and protects β-cells from apo... |
|
T60743 |
Vin-C01
|
|
|
|
Vin-C01 can be used for the research of type 2 diabetes mellitus that is a potent protective agent of pancreatic β-cells (EC 50 = 0.22 μM). Vin-C01 effectively protects β-cells from apoptosis induced by STZ and promotes ... |
|
T38764 |
Amylin (8-37), human
|
|
|
|
Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the abs... |
|
T35918 |
N-Arachidonoyl Taurine
|
|
|
|
N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is... |
|
TP2018 |
GIP, human
|
GIP (human) |
|
|
Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Al... |
|
TP1954 |
PHM-27 (human)
|
|
|
|
Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets di... |
|
T76028 |
Amylin (IAPP), feline TFA
|
|
|
|
Amylin (IAPP), feline TFA, a 37-amino acid polypeptide derived from felines, stands as a principal secretion product of the pancreatic islets' β-cells. This regulatory peptide notably inhibits the secretion of insulin an... |
|
T35625 |
Aminoacetone (hydrochloride)
|
|
|
|
Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases. It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes pa... |
|
TP2020 |
[Pro3]-GIP (Mouse)
|
|
|
|
GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intra... |
|
T71981 |
Gliclazide-d4
|
|
|
|
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. ... |
|
T69380 |
Cinnamic acid, hydrazide
|
|
|
|
Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various me... |
|
T68976 |
Piragliatin
|
|
|
|
Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptiv... |
|
T36408 |
Rhein-13C4
|
Rhein-13C4 |
|
|
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerei... |
|
T80060 |
Pyruvate carboxylase
|
|
Endogenous Metabolite
|
|
Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP. This enzyme is crucial for regulating whole-body energetics, influencing... |
|
T76333 |
(Ser8)-GLP-1 (7-36) amide, human
|
|
|
|
(Ser8)-GLP-1 (7-36) amide, human is a glucagon-like peptide-1 amide originating from glucagonogen, itself a cleavage product of the GLP-1 (1-36) amide peptide. This entero-insulinotropic hormone facilitates glucose-depen... |
|
TP1233 |
Amylin (8-37), rat
|
Amylin (8-37) (mouse, rat) |
|
|
Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) ... |
|
T83928 |
DA ZP1
|
|
|
|
DA ZP1 (diacetylated Zinpyr1), a highly sensitive fluorogenic Zn(II) sensor (KdZn2+= 0.6 nM), efficiently images and isolates pancreatic β-cells and β-like cells in vitro and purifies live stem cell-derived β-like cells.... |
|
T22014 |
8-CPT-2Me-cAMP, sodium salt
|
|
|
|
8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for act... |
|
T63019 |
GKA50 quarterhydrate
|
|
|
|
GKA50 quarterhydrate is a potent glucokinase activator with an EC50 value of 33 nM. GKA50 quarterhydrate is a glucose-like activator of β-cell metabolism in rodent and human pancreatic islets and a Ca2+-dependent regulat... |
|
T82317 |
GIP, rat
|
|
|
|
GIP (rat) (Glucose-dependent Insulinotropic Polypeptide), also known as Gastric Inhibitory Polypeptide, is a biologically active 42-amino acid peptide secreted by the K cells of the duodenum and jejunum following food co... |
|
T76480 |
Amylin (1-37) (human)
|
|
|
|
Amylin (1-37) (human) (hIAPP (1-37)), a peptide hormone found in pancreatic beta-cell secretory granules, features an amidated C-terminus and a disulfide bond between cysteine residues 2 and 7 [1]. |
|
T25739 |
Linogliride
|
McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida |
|
|
Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby ... |
|
T82329 |
GDI2-IN-1
|
|
|
|
GDI2-IN-1 (compound (+)-37), a GDP-dissociation inhibitor beta (GDI2) inhibitor, demonstrates potent inhibitory activity with an IC50 of 2.87 μM and a K D of 36 μM, and exhibits excellent in vivo antitumor efficacy in pa... |
|
T35639 |
Sulfatides (bovine) (sodium salt)
|
|
|
|
Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galacto... |
|
T82907 |
BDC2.5 Mimotope 1040-63
|
|
|
|
BDC2.5 Mimotope 1040-63 is a biologically active peptide employed in the investigation of type 1 diabetes (T1D), an autoimmune disease where T cells induce destruction of pancreatic islet β cells. This mimotope, originat... |
|
T83827 |
Adenosine-5'-O-(3-thiotriphosphate) sodium
|
ATPγS,Adenosine 5'-(γ-thio)-triphosphate |
|
|
Adenosine-5'-O-(3-thiotriphosphate) (ATPγS), an agonist of the purinergic P2Y11 receptor, prompts inositol phosphate accumulation in CHO-K1 cells harboring the human or canine P2Y11 receptor with EC50 values of 1.2 and 1... |
|
T25739L |
Linogliride fumarate
|
McN 3935,McN-3935,McN3935 |
|
|
Linogliride fumarate is the fumarate salt of Linogliride. Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassi... |
|
T82316 |
GIP, rat TFA
|
|
|
|
GIP, rat TFA (glucose-dependent insulinotropic polypeptide), a 42-amino acid peptide secreted by K cells in the duodenum and jejunum, promotes insulin release from pancreatic beta cells, supports beta cell proliferation,... |
|
T70882 |
Orlistat-d3
|
|
|
|
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase doma... |
